Meet MISTR: Easy, Free, At-Home PrEP Across the U.S.

July 03 2025

by Lachlan Probyn

For nearly a decade, Tristan Schukraft—already known for queer-forward ventures like Tryst Hotels and the iconic Abbey—has turned his focus toward making HIV prevention simple, accessible, and stigma-free. Enter MISTR, a telehealth service offering free PrEP (pre-exposure prophylaxis) and long-term HIV care, all without ever setting foot in a clinic.

Born out of Schukraft’s belief that healthcare should center queer lives, MISTR removes the cost, hassle, and awkward conversations that too often keep people from taking control of their sexual health. Today, it’s a lifeline for thousands of LGBTQ+ individuals across all 50 states, Washington D.C., and Puerto Rico.

From Hotels to Health: A Queer Vision

Schukraft’s background in queer hospitality—yes, he’s the mind behind Tryst Hotels and nightlife landmarks like The Abbey—makes him no stranger to the vibrant, diverse needs of the LGBTQ+ community. That same understanding now fuels MISTR’s mission: to erase barriers and make HIV prevention as routine as ordering groceries online.

It’s a natural extension of his belief that queer culture is about more than bars and Pride weekends—it’s about real safety, real well-being, and thriving every day.

How Does MISTR’s Free PrEP Work?

MISTR’s magic is in its ease. Everything is done online. You fill out a quick health questionnaire, upload a recent lab report—or request a free, discreet home-testing kit—and a licensed clinician reviews your file. Once approved, your prescription is shipped straight to your door. No awkward pharmacy runs, no waiting rooms, no out-of-pocket surprises.

PrEP is proven to reduce the risk of contracting HIV by up to 99% when taken as prescribed. But cost, lack of queer-competent doctors, and stigma still stop too many from accessing it. MISTR flips the script—combining telehealth convenience with LGBTQ+ care expertise to make staying negative simple and stress-free.

Not Just PrEP: DoxyPEP, Injectables, and More

MISTR’s offerings don’t stop at daily pills. In 2024, the platform added DoxyPEP, a preventative option to reduce bacterial STIs like gonorrhea and chlamydia after sex. Then in mid-2025, it began rolling out Lenacapavir, an injectable PrEP that requires just two shots a year.

This means more choices for more bodies and lifestyles—whether you’re a road warrior who forgets a daily dose, or just want the absolute easiest protection possible.

Free Really Means Free

MISTR’s approach relies on smart partnerships with labs, pharmacies, and assistance programs. The result? No copays, no insurance hassles, no surprise bills. You get the care you need, delivered discreetly—at no cost to you.

And it’s not just queer marketing fluff. MISTR recently surpassed 500,000 users. They even partner with major retail chains like Walmart in Georgia to expand access to free HIV test kits—reaching communities where stigma and lack of clinics still block too many from getting tested.

A Community-Rooted Approach

From day one, MISTR has been 100% LGBTQ-owned and operated. This means more than good optics; it means you’re getting care from a team that understands your reality—whether you’re closeted in a small town or living loud in a big city.

They know that barriers to PrEP aren’t just medical—they’re social, economic, and deeply personal. That’s why they make it easy, anonymous, and affirming.

More Than Medicine: A Path to Ending HIV

The CDC’s goal of ending the HIV epidemic by 2030 won’t be reached by clinics alone. Services like MISTR are showing what’s possible when we put the tools for prevention directly in people’s hands—without shame, cost, or gatekeeping.

If you’re a U.S. resident, you can sign up at heymistr.com and get started in minutes. Everything you need comes in the mail—medication, lab kits, follow-up reminders—and their support team stays with you every step of the way.

The Bottom Line

From Schukraft’s boutique hotels to your doorstep, the through-line is clear: when queer entrepreneurs center the community, lives change for the better. MISTR proves that sexual health can be easy, empowering, and stigma-free.

So if you’ve ever put off PrEP because it felt like too much hassle, too much money, or too much judgment—think again. With MISTR, it’s as simple as click, test, ship. And that’s a revolution worth raising a glass to—whether you’re on Duval Street, lounging at a Tryst Hotel, or just living your best, well-protected life.

Ready to get started? Visit heymistr.com to learn more.